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OUR RESEARCH

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OUR GOALS

Immediate goals: To understand the gut-brain mechanisms controlling dietary decisions and their effects on health and behaviour.

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Ultimate goals: To generate new scientific knowledge which could optimise human health and potential and promote a sustainable society.

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WHY ZEBRAFISH?

The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function. 

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It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages. 

Image by National Cancer Institute

TRANSLATION AND APPLICATION

Although we are a basic research lab, we also run translational projects in the domains of nutrition and human health (e.g. microbiome and multi-omics studies on human cohorts, clinical neuroimaging), drug discovery, and aquaculture. 


We continue to be interested in forming impactful collaborations with industry and clinical partners.  

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OUR TECHNIQUES

  • Functional Imaging

  • Multi-omics Approaches

  • Microbiome Analysis

  • Electrophysiology

  • Quantitative Behavioural Analysis

  • Circuit Manipulation 

  • Genetic Modelling 

  • Pharmacological Screening

  • Machine Learning

  • Whatever you can bring! 

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KEY COLLABORATORS

Zebrafish Neural Circuits and Disease Models 

  • Suresh Jesuthasan (LKC Medicine, NTU)

  • Ajay Mathuru (Yale-NUS College)

  • Stefan Oehlers (Infectious Diseases Labs, A*STAR)

  • Florian Engert and Mark Fishman (Harvard University)

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Technology Development 

  • Peter Torok (SCELSE, NTU)

  • Shi Yan Ng (Institute of Molecular and Cell Biology, A*STAR)

  • Maria De Iorio (NUS Statistics)

  • Kok Hao Chen (Genome Institute of Singapore, A*STAR)

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Brain-Body Initiative and Multi-omics

  • Division of Neurometabolism (Institute of Molecular and Cell Biology, A*STAR)

  • GUSTO research team (Singapore Institute of Clinical Sciences, A*STAR)

  • Anand Andiappan (Singapore Immunology Network, A*STAR)

  • Radoslaw Sobota (Institute of Molecular and Cell Biology, A*STAR

  • James Chan (Singapore Institute of Food and Biotechnology Innovation, A*STAR)

  • Eric Chan (NUS Pharmacy)

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Food and Nutrition / Aquaculture

  • Alvin Loo and Huang Dejian (Food Science and Technology, NUS)

  • Xiaodi Su and Laura Sutarlie (Institute of Materials Research and Engineering, A*STAR

  • Shubha Vij and Marie Tan (Republic Polytechnic)​

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