OUR RESEARCH

OUR GOALS

Immediate goals: To understand the gut-brain mechanisms controlling feeding and dietary decisions, as well as other motivated behaviours.

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Ultimate goals: To generate new scientific knowledge which could optimise human health and potential and promote a sustainable society.

WHY ZEBRAFISH?

The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function. 

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It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages. 

OUR TECHNIQUES

• Functional Imaging

• Electrophysiology

• Quantitative Behavioural Analysis

• Circuit Manipulation 

• Omics Approaches

• Genetic Modeling 

• Pharmacological Screening

• Machine Learning

• Whatever you can bring! 

KEY COLLABORATORS

• Shi Yan Ng (Institute of Molecular and Cell Biology, A*STAR)

• Anand Andiappan (Singapore Immunology Network, A*STAR)

• Johan Eriksson (Singapore Institute of Clinical Sciences, A*STAR)

• Shyam Prabakhar (Genome Institute of Singapore, A*STAR)

• Xiaodi Su and Laura Sutarlie (Institute of Materials Research and Engineering, A*STAR)

• Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR)

• Suresh Jesuthasan (LKC Medicine, NTU)

• Peter Torok (SCELSE, NTU)

• Alvin Loo and Huang Dejian (Food Science and Technology, NUS)

• Ajay Mathuru (Yale-NUS College)

• Lena Ho (Duke-NUS)

• Shubha Vij and Marie Tan (Aquaculture, Republic Polytechnic)

• Katheline Hua (Aquaculture, James Cook University Singapore)

TRANSLATION AND APPLICATION

Although we are a basic research lab, we run a number of translational projects in the domains of human health (e.g. multi-omics studies on human cohorts), drug discovery, and aquaculture. 

We continue to be interested in forming impactful collaborations with industry and clinical partners.