OUR RESEARCH

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OUR GOALS

Immediate goals: To understand the gut-brain mechanisms controlling feeding and dietary decisions, as well as other motivated behaviours.

Ultimate goals: To generate new scientific knowledge which could optimise human health and potential and promote a sustainable society.

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WHY ZEBRAFISH?

The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function. 

It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages. 

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OUR TECHNIQUES

  • Functional Imaging

  • Electrophysiology

  • Quantitative Behavioural Analysis

  • Circuit Manipulation 

  • Omics Approaches

  • Genetic Modeling 

  • Pharmacological Screening

  • Machine Learning

  • Whatever you can bring! 

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KEY COLLABORATORS

  • Shi Yan Ng (Institute of Molecular and Cell Biology, A*STAR)

  • Anand Andiappan (Singapore Immunology Network, A*STAR)

  • Johan Eriksson (Singapore Institute of Clinical Sciences, A*STAR)

  • Shyam Prabakhar (Genome Institute of Singapore, A*STAR)

  • Xiaodi Su and Laura Sutarlie (Institute of Materials Research and Engineering, A*STAR)

  • Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR)

  • Suresh Jesuthasan (LKC Medicine, NTU)

  • Peter Torok (SCELSE, NTU)

  • Alvin Loo and Huang Dejian (Food Science and Technology, NUS)

  • Ajay Mathuru (Yale-NUS College)

  • Lena Ho (Duke-NUS)

  • Shubha Vij and Marie Tan (Aquaculture, Republic Polytechnic)

  • Katheline Hua (Aquaculture, James Cook University Singapore)

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TRANSLATION AND APPLICATION

Although we are a basic research lab, we run a number of translational projects in the domains of human health (e.g. multi-omics studies on human cohorts), drug discovery, and aquaculture. 


We continue to be interested in forming impactful collaborations with industry and clinical partners.