OUR RESEARCH

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OUR GOALS

Immediate goals: To understand the gut-brain mechanisms controlling feeding and dietary decisions.

Ultimate goals: To generate new scientific knowledge which could optimize human health and potential and promote a sustainable society.

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WHY ZEBRAFISH?

The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function. 

It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages. 

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OUR TECHNIQUES

  • Functional Imaging

  • Electrophysiology

  • Quantitative Behavioural Analysis

  • Circuit Manipulation 

  • Omics Approaches

  • Genetic Modeling 

  • Pharmacological Screening

  • Machine Learning

  • Whatever you can bring! 

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KEY COLLABORATORS

  • Suresh Jesuthasan (LKC Medicine, NTU)

  • Peter Torok (SCELSE, NTU)

  • Alvin Loo and Huang Dejian (Food Science and Technology, NUS)

  • Ajay Mathuru (Yale-NUS College)

  • Lena Ho (Duke-NUS)

  • Shubha Vij and Marie Tan (Aquaculture, Republic Polytechnic)

  • Katheline Hua (Aquaculture, James Cook University Singapore)

  • Anand Andiappan (Singapore Immunology Network, A*STAR)

  • Johan Eriksson and Anna Fogel (Singapore Institute of Clinical Sciences, A*STAR)

  • Shyam Prabakhar (Genome Institute of Singapore, A*STAR)

  • Xiaodi Su and Laura Sutarlie (Institute of Materials Research and Engineering, A*STAR)

  • Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR)

  • Shi Yan Ng (Institute of Molecular and Cell Biology, A*STAR)

  • Cheng Li (University of Alberta & Bioinformatics Institute, A*STAR)

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TRANSLATION AND APPLICATION

Although we are a basic research lab, we run a number of translational projects and collaborations in the domains of human health (e.g. cohort studies) and aquaculture. 


We continue to be interested in forming impactful collaborations with industry and clinical partners.