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OUR RESEARCH

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OUR GOALS

Immediate goals: To understand the gut-brain mechanisms controlling brain function and behaviour, especially mental and cognitive health

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Ultimate goals: To leverage our understanding of brain-body crosstalk towards human health and well-being

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KEY RESEARCH AREAS

Gut-Brain Axis

Nutrient-Microbiome Interactions

Neuro-Immune Interactions

Metabolic and Brain Health

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WHY ZEBRAFISH?

The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function. 

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It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages. 

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OUR TECHNIQUES

  • Functional Imaging

  • Multi-omics Approaches

  • Microbiome Analysis

  • Electrophysiology

  • Quantitative Behavioural Analysis

  • Circuit Manipulation 

  • Genetic Modelling 

  • Pharmacological Screening

  • Machine Learning

  • Whatever you can bring! 

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TRANSLATION AND APPLICATION

Although we are a basic research lab, we also run translational projects in the domains of nutrition, human health and ageing (e.g. microbiome and multi-omics studies, clinical neuroimaging), as well as aquaculture.

We use the zebrafish as a platform for target prioritisation and mechanistic validation. 

We continue to be interested in forming impactful collaborations with industry and clinical partners.  

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©2020 by Caroline Wee Lab

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