OUR RESEARCH
OUR GOALS
Immediate goals: To understand the gut-brain mechanisms controlling dietary decisions and their effects on health and behaviour.
Ultimate goals: To generate new scientific knowledge which could optimise human health and potential and promote a sustainable society.
WHY ZEBRAFISH?
The zebrafish is a vertebrate that shares genes, physiology, gut-brain anatomy and behaviours with mammals, while at the same time being small and tractable enough to gain a holistic perspective of organ and brain function.
It is also cost-effective and amenable to high-throughput genetic and pharmacological screening studies, particularly at the larval stages.
TRANSLATION AND APPLICATION
Although we are a basic research lab, we also run translational projects in the domains of nutrition and human health (e.g. microbiome and multi-omics studies on human cohorts, clinical neuroimaging), drug discovery, and aquaculture.
We continue to be interested in forming impactful collaborations with industry and clinical partners.
OUR TECHNIQUES
Functional Imaging
Multi-omics Approaches
Microbiome Analysis
Electrophysiology
Quantitative Behavioural Analysis
Circuit Manipulation
Genetic Modelling
Pharmacological Screening
Machine Learning
Whatever you can bring!
KEY COLLABORATORS
Zebrafish Neural Circuits and Disease Models
Suresh Jesuthasan (LKC Medicine, NTU)
Ajay Mathuru (Yale-NUS College)
Leslie Beh (Institute of Molecular and Cell Biology, A*STAR)
Yan Chuan (Institute of Molecular and Cell Biology, A*STAR)
Stefan Oehlers (Infectious Diseases Labs, A*STAR)
Sudipto Roy (Institute of Molecular and Cell Biology, A*STAR)
Florian Engert and Mark Fishman (Harvard University)
Technology Development
Peter Torok (SCELSE, NTU)
Shi Yan Ng (Institute of Molecular and Cell Biology, A*STAR)
Maria De Iorio (NUS Statistics)
Shyam Prabakhar and Kok Hao Chen (Genome Institute of Singapore, A*STAR)
Brain-Body Initiative and Multi-omics
Anand Andiappan (Singapore Immunology Network, A*STAR)
Radoslaw Sobota (Institute of Molecular and Cell Biology, A*STAR
Eric Chan (NUS Pharmacy)
Division of Neurometabolism (Institute of Molecular and Cell Biology, A*STAR)
GUSTO research team (Singapore Institute of Clinical Sciences, A*STAR)
Food and Nutrition
Alvin Loo and Huang Dejian (Food Science and Technology, NUS)
Katheline Hua (James Cook University Singapore)
Aquaculture
Xiaodi Su and Laura Sutarlie (Institute of Materials Research and Engineering, A*STAR
Shubha Vij and Marie Tan (Republic Polytechnic)