PUBLICATIONS (CW LAB)
* Co-first author
§ Corresponding author
CHAGANTY V*, CHENG RK, SHEN K, ZHANG N, DOBLADO GJ, ONG S, TAN S, THAM VYY, CHOI JH, HALPERN ME, CHEW WL, ANDIAPPAN AK, LUO SX, WEE CL§. "COMPARATIVE TRANSCRIPTOMICS OF LATERAL HYPOTHALAMIC CELL TYPES REVEALS CONSERVED GROWTH HORMONE-TACHYKININ DYNAMICS IN FEEDING" (IN REVISION, BIORXIV PREPRINT)
Led by Vindhya Chaganty (Scientist), in a collaborative effort between multiple A*STAR institutes (IMCB, GIS, and SIgN), this paper takes a cross-species look at the lateral hypothalamus, an important region of the brain for hunger control. We identify a novel conserved cell type, regulated by growth hormone, which shows dynamic changes in gene expression and activity over feeding, contributing towards accumulating evidence that growth hormone may be a "hunger hormone" that can acutely regulate food intake.
CHENG RK*, TAN XMJ*, CHUA KX, TAN JXC, WEE CL§. "OSMOTIC STRESS UNCOVERS CORRELATIONS AND DISSOCIATIONS BETWEEN ZEBRAFISH ANXIETY ENDOPHENOTYPES"
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022
Short companion primary research report for the review article below, also published Frontiers special topic: Using Zebrafish to Investigate Normal Development and Function of the Nervous System: How nervous system disorders occur and testing of potential therapeutic approaches.
Ruey-Kuang Cheng (Senior Research Fellow) and Jazlynn Tan (Research Officer) share joint first authorship for developing, validating and analyzing data from the multiple behavioral assays utilized. Also featured is a new machine-based analysis method that Jazlynn developed for quantifying food intake via gut fluorescence (analysis code on our lab's GitHub). Kai Xin Chua (research officer) conducted all experiments. Cheryl Tan was a SGUnited trainee turned research officer who helped perform and optimize initial pilot experiments.
TAN XMJ, ANG JWR, WEE CL§. "LARVAL ZEBRAFISH AS A MODEL FOR MECHANISTIC DISCOVERY IN MENTAL HEALTH" [REVIEW ARTICLE]
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022
Review article published in the Frontiers special topic: Using Zebrafish to Investigate Normal Development and Function of the Nervous System: How nervous system disorders occur and testing of potential therapeutic approaches.
It was primarily written by Jazlynn Tan, an A*STAR scholar who did a 6-month rotation as a research officer in the lab, with one section also written by Ryan Ang, an A*STAR science awardee and Singapore polytechnic intern.
PUBLICATIONS (CW LAB x BRAIN-BODY INITIATIVE)
* Co-first author
§ Corresponding author
HUANG P, TINT MT, LEE M, NGOH ZM, GLUCKMAN P, CHONG, YS, HAN W, FU Y, WEE CL, FORTIER MV, ANG KK, LEE YS, YAP F, ERIKSSON, JG, MEANEY MJ, TAN AP§ "FUNCTIONAL ACTIVITY OF THE CAUDATE MEDIATES THE RELATION BETWEEN EARLY CHILDHOOD MICROSTRUCTURAL VARIATIONS AND ELEVATED METABOLIC SYNDROME SCORES"
NEUROIMAGE, 2023
PUBLICATIONS (CW LAB x AQUACULTURE)
* Co-first author
§ Corresponding author
TANAKA Y, SALLEH NABM, TAN M, VIJ S, WEE CL, SUTARLIE L§, SU X § "A CORTISOL APTASENSOR FOR NON-INVASIVE DETECTION OF FISH STRESS"
BIOMOLECULES, 2024
In these back-to-back publications, our team (A*STAR IMCB and IMRE, with Republic Polytechnic) characterises stress dynamics in a locally farmed fish species, Asian sea bass, by measuring cortisol levels in tissue and surrounding water in a farm-scale Recirculating Aquaculture System. We also develop a novel cortisol sensor that is faster and more sensitive than traditional ELISA assays. Our results add to a body of evidence suggesting that on-farm monitoring of water cortisol could be a non-invasive method of early stress detection in aquaculture, preventing productivity losses.
PUBLICATIONS (RESEARCH BEFORE CW LAB)
* Co-first author
§ Corresponding author